Osrs kudos guide1/31/2024 Just make sure you do at least 100 damage to avoid getting punished for being AFK. You shouldn’t have to click more than 2-3 times per game which is pretty chill while watching some YouTube, Netflix, or doing some chores. With auto-retaliate on, you should be able to AFK for a little bit.Īttack the portal once it spawns. What I do for this strategy is run toward one portal at the start of the game and just attack a monster. The best way to play pest control to grind out void is to play the minigame semi-AFK. Defiler Ranged These guys can hit the void knight over the walls How to AFK Pest Control Torcher Magic These guys can hit the void knight over the walls. Ravager Melee These destroy gates and barricades. Avoid killing them near barriers, gates or void knight. Brawler Melee Big boys that will block you Shifter Melee These guys teleport through walls (and attack the void knight in the center) Splatter Melee Explodes when killed. Monster Attack Style Side Notes Spinner Melee Spinners are annoying and heal your portals. Here’s some information about them, their attack style, weakness & sidenotes. Pest control has 7 monsters that get spawned by the portals. However, most of the time this area is pretty crowded in the official worlds which is why it’s better not to guard him and focus on a portal instead. Some players should be on guard duty and kill the monsters that spawn around the Void Knight. For each destroyed portal, he heals 50 hitpoints. The only way to heal him is to destroy portals. He has 200 hitpoints and needs to be protected from the monsters. The Southeastern Portal is weak to Crush Void KnightĪt the center of the minigame, you can find the Void Knight.The Southwestern Portal is weak to Stab and Slash.While all weapons can be used to attack the portals, they each have their own weakness to a certain combat style: Whenever a portal is destroyed, the void knight gets healed for 50 hitpoints. The next shield portal opens 30 seconds later. ![]() After 15 seconds, the first shield gets released and is revealed in the HUD. Pest Control PortalĪt the start of Pest Control, all four portals are shielded up. On the left side, you can see the hitpoints of the Void Knight as well as your current damage output. Whenever a portal opens up, this will be indicated on the HUD. The right side features the four portals and their health. Pest Control HUDĪt the top of your screen, you will find the Pest Control HUD. This map also indicates their individual weaknesses. Then, behind gates, you have 4 different portals which need to be destroyed. Pest Control MapĪt the center of the map you have the Void Knight, which needs to be protected from damage from the monsters. The main objective of Pest Control is to destroy each of the 4 portals that spawn before the Void Knight dies. Since it’s team-based, you are almost guaranteed to win every round while playing in the official worlds regardless of your input. Pest Control is a very straightforward minigame that doesn’t really have a learning curve compared to some other minigames. The closest boat to the bank is the Novice boat, the middle one is the intermediate boat and the furthest one is the veteran boat. To start a game of Pest Control, hop to the official Pest Control world (344) and enter one of the three boats.
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Rhino for mac review1/31/2024 ![]() ![]() This works like Apple's Universal Control feature in MacOS Monterey, with the added benefit of even working between MacOS and Windows. The MX Master 3 for Mac is also distinctive for its comfortable and ergonomic design, and it’s can be used across multiple computers and operating systems thanks to Logitech's Flow app. It's a very clever way to work your way around your Mac. While this is pressed, you can swipe your mouse in the same way you would on a trackpad to perform native MacOS gestures. As well as that, there's a built-in gesture-control button at the bottom of the thumb rest. The latter is ideal for zooming through long web pages or lengthy documents. It charges via USB-C and can last 70 days on a full charge.Īside from those Mac-specific features, you get a MagSpeed wheel that can automatically switch between accurate ratchet clicking and fast, free-flowing scrolling. This comes with improved Bluetooth performance and a Space Gray color compared to the regular MX Master 3 wireless mouse. Rhino for Windows has some additional commands not present in Rhino for Mac which can be found here.Logitech's MX Master 3 is among the best mice for Mac, and now Logitech has released a version just for the Mac. Rhino is nearly the same on both platforms. What's the difference between Rhino for Mac and Rhino for Windows? In Rhino 6, hundreds of minor bugs have been fixed and similar features consolidated into single commands, making Rhino much more refined. Small quirks add up to painful paper cuts over the course of a prolonged modelling session. Make2D has been completely rewritten to provide faster, better, cleaner, more customisable results. There's a great new option to license Rhino using the Cloud Zoo, as well as new System Requirements. Rhino is easier to install, license, and configure than ever. It's now easier to convey accurately and clearly the what and the how of your design. Many parts of the documentation workflow have been refined, from a completely reworked annotation-style interface, to better DWG support, and RichText throughout. Modelling is just one part of the design process you also need to show how to build what is on the screen. In some conditions, display speed can be up to 300% faster. This results in fewer GPU-specific display glitches and more consistent, beautiful, and frequent frames, even with large models. Rhino's new display pipeline is faster, more stable, and uses features found on modern graphics hardware, like GPU sensitive shaders and memory optimisations. With major changes to Rendering, Materials, or just plain capturing the viewport, it's now easier and faster to present, discuss, make decisions, and iterate. Rhino has been improved with the aim of helping you present your work: be it "quick and dirty" or "high-res glossy". Now as a fully-fledge part of Rhino, users have a solid foundation for many incredible third-party components ranging from environmental analysis to robotic control.ĭuring nearly every phase of design, you need to communicate to clients, customers, collaborators, or the public at large. In Rhino 6, Grasshopper - the popular visual programming language - has been fully embraced. For those new to 3D modelling on Mac, looking for a cost-effective application with a large user-base, high-level of accuracy and without complex or restrictive licensing arrangements, Rhino for Mac is ideal. It is now possible for existing Rhino 3D users to reliably model on an iMac, MacBook or Mac Pro. With Rhino, you can be sure your files are compatible with hundreds of products and workflows. Rhino for Mac liberates Mac users from running Rhino on a physical or emulated Windows environment, and all Rhino for Mac purchases will be for a universal Rhino 6 licence which are interchangeable between Mac and Windows installers. ![]() You'll feel right at home with this native application that feels familiar to both Mac users and experienced 3D modellers. Rhino, the industry standard NURBS engine is here for Mac OS X. Drive genius mac free1/31/2024 ![]() MacFly Pro can handle it very quickly for you. All you need to do is to use a cleaning app with an uninstalling feature. - /Users/Library/Application Support/DriveGenius.Be sure you delete the following, if they are still there: Then it is recommended to go through your files and to manually delete all the data associated with Drive Genius. Then, drag-and-drop the app to Trash and confirm uninstalling. First of all, stop all the processes of Drive Genius (with the help of Cmd+opt +Esc choose Drive Genius and click on Force Quite). If you decide to remove this app, too, here are your options.įirst option is to do it manually. There are quite a lot of inquiries on Mac forums from people who have problems uninstalling Drive Genius. There are three plans you can choose from. ![]() Drive Genius 5 app is not free and requires a one-time payment. With the demo up and running you can test out available features for up to 30 days. The download link is provided by email with a unique demo key. ![]() Rebuild – this feature can find the lost file names if the data is not removed.Repair – this tool is able to fix the majority of logical file problems.Consistency Check – this one looks through formatted drives and makes sure there are no errors and data issues.Active files – this feature shows you files and programs that are active at the moment.Instant DrivePulse – it performs basic DrivePulse operations and tells you if there are problems.Physical Check – this feature aims to check and fix different hardware issues connected to damaged drive and cable or connection problems.BootWell – this tool builds up an additional startup drive in order to optimize or fix you primary drive (needed for repair, defragment, advanced physical check, etc.).Additionally, this feature automatically looks for malware in all of your downloaded files. The list of such malware is updated on the daily basis. Malware Scan – when you run Malware Scan, it looks through all of your files in search for all the currently known malware.By exploring the Protect module, you can see what features it offers. Maybe you didn’t notice it, as Apple was fast to fix it, but for some time, anyone could log in to your system without any passwords.ĭrive Genius 5 claims to protect you from all the possible issues. The last security flaw stroke not long ago, with the update to High Sierra. The fact that there have been a considerable amount of viruses and security issues only tells us that some kind of protection wouldn’t hurt. It is not surprising, as you can only be amazed by the skills of modern hackers and the number of nowadays scams and viruses that potentially can affect Macs, too. However, such programs (free or paid) for OSX do exist and people do install them. ![]() Macs have always had the reputation of well secured devices that do not need any additional antivirus programs. Information– this tab gathers all of the information you may need to find on your Mac’s system.ĭrive Genius for Mac – The Protecting Part.IconGenius™ – here you can choose an icon for any folder or drive.Initialize– this one works with preparation of new drives or deleting the old ones (can be used to prepare a drive for work with Windows or different camera cards).Secure Erase deletes the data with no possibility of recovery.Clone– this feature figures out the configuration of your drive and copies it to the new drive.Good chances are that you don’t need many of them. Find Large Files – this is a useful feature that allows you locating all the big files on your Mac.Find Duplicates – this tool looks for identical files that may clutter your system.(The feature is not available on macOS High Sierra (10.13) or higher) Repartition – Repartition – this feature shows you all of your Mac partitions and offers you to organize or delete them in order to optimize the space.The Clean Up module has 8 different tools to try. Speed tab claims to measure your optimal drive performance.Defragment – you can learn more about this process here.The Speed Up module offers you two features: We’ll talk about the Protect one a bit later for now, let’s focus on the cleaning and speeding parts. In all, if you download Drive Genius 5 (or upgrade from earlier versions), you can explore through 3 Modules – Protect, Speed Up and Clean Up. Drive Genius 5 also combines two big types of tools for a safe and fast Mac work – it offers both cleaning set of tools and protection from malware and viruses. The competition is big, and almost every software developer tries to add more unique features to their app or combine different kinds of tools to make their product more comprehensive. There are quite a lot of mac cleaning tools out there at the moment. Drive Genius Mac: Comprehensive Tool for Cleaning and Protection Tyler the creator wallpaper1/31/2024 ![]() 900x1200px Tyler The Creator ` Tyler The Creator in 2020, taylor the creator aesthetic HD phone wallpaper.Tyler the creator, Tyler the creator, collage wall, Asap Rocky And Tyler HD wallpaper 1125x778px Tyler, the Creator with Kendall Jenner and A$AP Rocky.750x1334px Tyler The Creator iPhone - & Background, Asap Rocky and Tyler the Creator HD phone wallpaper.715x1280px flower boy, tyler the creator phone HD phone wallpaper.1280x2542px My husband made a cool Igor : tylerthecreator, Tyler, The Creator, Igor HD phone wallpaper.Tyler the creator, Tyler the creator, Asap Rocky And Tyler HD wallpaper 1125x873px Tyler, The Creator and A$AP ROCKY.1500x2900px See You Again Tyler The Creator HD phone wallpaper.1080x2400px Tyler the Creator Wolf Album Cover on Dog HD phone wallpaper.1272x2262px Mobile Tyler, the Creator - Flower Boy : HipHop HD phone wallpaper.1125x2436px Tyler the creator, Tyler the creator, Album art design, tyler the creator wolf HD phone wallpaper.899x1349px Nathan on Men's outfits, Tyler the Creator HD phone wallpaper.1200圆75px Story Behind Tyler The Creator's 'Call Me If You Get Lost' Album Cover.Tyler the creator, Tyler the creator, Rap, Asap Rocky And Tyler HD phone wallpaper 767x1041px fight club tyler durden HD phone wallpaper.2560x1440px Flower Boy, tyler the creator igor HD wallpaper.1080x1920px love these guys, Asap Rocky and Tyler the Creator HD phone wallpaper.1280x720px What You Need to Know About Tyler, the Creator's 'Call Me If You Get Lost' HD wallpaper.768x1365px tyler the creator 42, Asap Rocky and Tyler the Creator HD phone wallpaper.1125x2000px Tyler, The Creator Igor HD phone wallpaper. ![]() 1200x744px Tyler, The Creator wants you to be IGOR for Halloween, Tyler, The Creator, Igor HD wallpaper.750x1250px Tyler the Creator Phone HD phone wallpaper.1349x1687px Tyler The Creator Igor iPhone - Tip HD phone wallpaper.2160x3840px Tyler, The Creator Igor HD phone wallpaper.750x1334px Tyler The Creator 2022, flower boy iphone HD phone wallpaper.719x1280px tyler the creator aesthetic HD phone wallpaper.675x1200px Robbie, Asap Rocky and Tyler the Creator HD phone wallpaper.2880x2560px tyler the creator aesthetic pc HD wallpaper.1024x1024px IGOR Album Cover, tyler the creator earfquake HD phone wallpaper.736x1309px Alone again, sad, dark, anime HD phone wallpaper.1920x1080px tyler the creator igor computer HD wallpaper.1152x2048px Tyler, The Creator Igor, Tyler, The Creator, Igor HD phone wallpaper.1920x1080px IGOR : tylerthecreator, tyler the creator computer HD wallpaper.1920x1080px Album Review: Tyler, the Creator IGOR, Tyler, The Creator, Igor HD wallpaper.1920x1080px Igor, Tyler, The Creator, Igor HD wallpaper.1272x2262px Tyler the Creator HD phone wallpaper.719x1280px Tyler The Creator Aesthetic -, Tyler, The Creator, Igor HD phone wallpaper.2880x1620px Tyler The Creator Flower Boy, Tyler, The Creator, Igor HD wallpaper.1548x1024px Tyler, The Creator EARFQUAKE, Igor HD wallpaper.2560x1440px tyler the creator igor computer HD wallpaper. ![]()
Super hexagon music download1/31/2024 ![]() ![]() Also, the game was designed to have digital controls, so control via mouse motion is something that will not be implemented, so don`t wait for it. Regarding controls, I didn`t see a big difference between playing with keyboard and with a gamepad. It does cause frustration quite a few times (there are some cheap deaths in the game). ![]() I`m 5h into it, beat the first two levels (Hexagon and Hexagoner) and am far from done with it. Yeah, it`s extremely hard as well, but this is intended. This is an extremely fun and addictive minigame. It does cause frustration quite a few Anyone who played the Super Gravitron in VVVVV knows what Terry Cavanagh can do in a small minigame. Anyone who played the Super Gravitron in VVVVV knows what Terry Cavanagh can do in a small minigame. Samsung kies for note 3 download1/31/2024 ![]() They should have allowed for standard media sharing and syncing protocols, which make it easy to use backup tools. They would have freely distributed any updates and drivers, instead of tying them up into a particular USB or installation. Poor User experience – Samsung did not put a lot of thought into the user's experience when they came up with Samsung Kies. Resource Hungry – Samsung Kies 3 is resource hungry and may make your computer crash several times. Samsung should include these in their instructions. You have to turn off USB debugging, and close applications on the phone. However, there are other functions that are necessary for this error to be removed. Lack of proper instructions – when Samsung users get an error message, they are simply asked to reconnect the device by unplugging the USB cable. Most users are happy with the Kies 3 Samsung tool. There is no solution put forward for this, and it only happens to a few. They claim that it duplicates the outlook contacts and basically messes with the organization of their computers. You should install Samsung Kies 3 on a powerful laptop or computer so it can work well.īugs – There are users who have complained about the proliferation of bugs in their computers and phones after using Samsung Kies 3. People take HD videos on Samsung devices and these may take longer to transfer. The tool may take a lot of resources, especially when you are syncing and storing huge files. Slow Speed – When it comes to speed, some users say that the tool takes too long to sync or move data from the phone to the computer and vice versa. This is a frustrating way of dealing with this issue, but it is the only one for now. To solve this problem, you have to disconnect and reconnect the USB cable from the computer. However, with Mac computers, users have said that the software tends to disconnect and become unresponsive. With Samsung Kies, the main issues revolve around:Ĭonnectivity – When you connect the device to your computer, it is immediately recognized by Samsung Kies. Part 3: The main issues about Samsung Kies 3Īs with all software, there are issues that do arise from users all over the world. Finally, Click Sync and let the process be completed. You will be sent to the Sync Window, where you can select the items and accounts that you would like to sync. Connect the phone to your computer and then click on Sync. You can now sync your online accounts to your mobile devices using Samsung Kies. How to Sync your Samsung using Samsung Kies 3 Once selected, click on restore and the data will be sent back to your phone. Step 4) Should you ever need to restore the data, go to Backup/Restore, click on the folder that you need, and find the latest backup file. Step 3) once the selection is done, simply click on the backup button and then wait for the process to be completed. ![]() You can also simply allow the tool to backup your phone whenever it is connected to the computer via the USB cable. Step 2) Choose Backup/Restore and then choose the data that you want to backup. The phone will soon be listed in the software. Step 1) Start Samsung Kies and then connect the phone to the computer using a USB cable. If it gets stolen or ruined, then you can restore the data to a new phone and continue as you normally did. It is important that you back up the data on your mobile device regularly. How to backup and restore using Samsung Kies 3 After that, you can import or export them to your computer. They will then be shown on the Window on the right. You click on contacts, Photos, Music, Podcasts, Videos, etc. You can now choose which files you want to transfer. ![]() Step 2 – Select what you want to transfer When you connect the device to your computer via USB cable, it will be recognized and all data that is on the phone will be displayed on the home screen. Using the appropriate download link, download this tool and install on your computer. Importing and exporting files using Samsung Kies 3 Here are these three functions explained in detail. ![]() Samsung Kies 3 can be used to carry out several functions such as exporting and importing files, backing up the phone, and finally syncing it with your online accounts. Toyota hybrid corolla1/30/2024 Output for the 2.0-litre system rises to 196hp while the 0-62mph is down by almost half a second to 7.5 seconds and the combined cycle CO2 figure is expected to fall 3g/km to 107g/km. CO2 emissions are expected to remain the same at 102g/km. Total power for the 1.8-litre system now stands at 140hp, shaving off 1.7 seconds from the 0-62mph time, which stands at 9.2 seconds. ![]() As a result, the powertrains deliver extra power, improved performance and drivability, with unchanged or lower CO2 emissions. The current 1.8- and 2.0-litre petrol hybrid powertrains will still be offered but benefit from a redesign of the power control unit and transaxle motor while the lithium-ion battery is more powerful, but smaller and up to 18kg lighter. Higher grades of the hatchback and Touring Sports models also gain new bi-LED headlights with an adaptive high-beam system.īigger changes have been made to the powertrain and electronics with the adoption of new fifth-generation Toyota hybrid electric technology. ![]() Minor revisions to design will introduce new exterior features and colours, along with latest interior trims, upholsteries and finishes. The updated line-up goes on sale in Europe during the first quarter of 2023, comprising the hatchback and Touring Sports wagon in the UK, following the recent departure of the saloon, while the previously revealed Corolla SUV will also arrive next year. It’s also racked up record global sales of more than 50 million units across all 12 generations since 1966. The current 12th-generation Corolla range launched three years ago and remains a core volume model for the brand in Europe – it’s the carmaker’s second best-selling model in the region. That shouldn’t worry owners – this is the sensible sedan after all.The updated line-up brings enhanced design with new fifth-generation Toyota hybrid electric technology The 103kW 1.8-litre petrol engine combines with the electric motor to give reasonable shove, while independent rear suspension helps give a well-balanced, comfortable ride and good roadholding.įat eco tyres help absorb bumps but aren’t the grippiest. It’s a lovely, relaxing drive and you never need plug the car in: the battery recharges itself when coasting or braking. These hybrids can silently start and drive up to 50km/h using just the battery and electric motor. This entry-level has a $1000 pack to add rear cross-traffic alert and blind-spot monitor arguably the two most helpful driver aids. It’s safe and good to drive, especially in EV modeĮvery Corolla gets a strong safety package including advanced auto emergency braking, intersection collision avoidance and radar cruise control. At least you get LED lights, 16-inch alloys, smart entry and start, built-in satnav and climate control. Rear space is acceptable – and far better than the Corolla hatchback’s – but it’s still a bit claustrophobic and lacks air vents. ![]() The cabin colour scheme is decidedly grey-on-grey and the 8-inch infotainment screen looks tacked-on, although functionality, build quality and wireless Apple CarPlay (wired Android Auto) work in its favour. This first-rung Corolla’s steering wheel feels too cheap and plastic, the door tops are rock hard and fabric on the (admittedly very comfy) seats is far from plush. You need to adjust your expectations of what a $35k small car should include. It doesn’t feel like a $35,000 car inside Diablo 2 resurrected andariel bug1/30/2024 ![]() This is why you see people joining beginner games and farming the bosses in those games. This will mark the bosses with quest drop. If you wish to get quest drop for farming bosses simply create a game with a character that has not killed those bosses for their quests. Character screen will NOT update and will display them as normal. The resistances given for rescuing Anya are LOST when you die and will not come back until you reload the game. Teleport to the entrance of CS and then back to the last seal and open it.Īny monster that was arrgo’ed from the entrance to when you open that last seal will drop items. (The one that does not spawn any champion. When opening the last seal in the CS this will make the monsters also drop items. ![]() If you are doing NM Ancients and they are fire enchanted, don't stand next to them when they die no matter how much HP or resistance you have, you will die. Nightmare Ancient - Fire Enhanced Bug (Bad) Prevent spin attack by Talic by standing next to SW cliff edge.Ĥ. Then walk down until the merc disappears off your mini map and teleports to you. You want to keep your merc in that room by closing the door as soon as you go through it. Head down into jail level 3 then go back up to inner cloister. One common area Used to bug your merc, is the inner cloister. Why it’s bad: Your merc no longer can tank for you and all attacks are directed at you. This makes your mercenary untargetable by enemies with the exception of ranged attackes. (Can do this on all difficulties) - You must be the one who created this game for it to work.Įssentially all you need to do is get your merc stuck somewhere while you keep walking so he teleports you you. This will give you permanent increased item drops from then on. Once you kill Andariel for the first time go to town using Andy's TP (not your own) and talk to Warrive to go Travel East to Act 2 before Save & Quit. If you guys want I have some other info I’ve complied over the years. Mp3 gain portable1/30/2024 ![]() If changes need to be made, choose to apply the Track, Album, or Constant type of gain to the files. Simply press the Track or Album Analysis button and the volume levels will be calculated. The default target volume is 89dB which you can change up or down if you want (75.0 – 99.9). Drag and drop also works if you don’t run the program as administrator. To load MP3 files into the program you can select individual files and playlists using the Add File(s) button or use the Add Folder button to load whole albums or complete folders. MP3Gain does work on the latest Windows 10 but you need to download the correct version to avoid error messages when you start it. The program is open source but apart from new language translations, it hasn’t had any meaningful updates since 2005. MP3Gain was one of the first pieces of software that used ReplayGain to adjust the volume level of MP3 files nearly two decades ago. However, fewer programs can actually process the file and write the ReplayGain data to the file in the first place. Most modern music playing software and hardware can read the ReplayGain metadata inside MP3 files. Software That Uses ReplayGain To Adjust MP3 Volume This mode is especially useful if your album has music that continues from one track into the next without a break, such as live albums or classical music. Look at the same image above and you can see that all tracks are to be adjusted by the same amount, whether they are louder or quieter than the average. This has the advantage that quieter parts of an album will stay that way relative to the louder parts, but the overall volume of the album will change. All tracks will be altered by this amount only. It calculates the average volume level across all the selected tracks and then works out how much gain needs applying to reach the target level. This mode is suited to whole albums or related collections of songs. If the volume is already close to the target volume, the file will be skipped. ![]() ![]() The image above shows that all the songs have a different volume level so the track gain to be applied is different for each. Some songs may need a drop in volume to reach the target level, others may need an increase. The volume level for each individual song is calculated and the amount of gain needed for it to match the target volume is displayed. This mode is best used for collections of individual tracks that are completely separate from each other, like compilations or greatest hits albums. ReplayGain has two different modes to choose from and the software you use to adjust audio files using this method will usually have both available. The calculated settings are stored in the music file’s metadata so it can be undone and the file restored to its original volume level later on. What makes ReplayGain useful is the process is lossless and it can do this without re-encoding the audio file. It uses an algorithm to calculate a track’s overall perceived loudness and then adjusts the song to the required level, making the sound you actually hear more consistent across several songs. It’s not actually a program or piece of software but ReplayGain is an audio standard to measure the volume level of a music file. Here we show you another way that has some useful advantages. One way is to re-encode the file to the desired level, but this lowers the quality of the audio. The result is some tracks might be significantly louder or quieter than others. What you need to solve this problem is a program to alter the volume of the songs to a similar level so there are no sudden jumps between tracks when there shouldn’t be. ![]() Some individual tracks or whole albums will have been encoded by a different person or company using different methods. One of the problems you will have most likely come across if you have music from several different sources is that they don’t all have the exact same volume level. There is a multitude of different ways to get your music files from P2P networks, download services like iTunes, searching for MP3s on Google, or visiting Myspace. Many of us like to listen to music whether it’s in the car on the way to work, walking down the street or at home to relax. Keynote 5901/30/2024 ![]() ResultsĪt data cutoff, 749 pts (83% male, 73% ESCC) were randomized (373 pembro + chemo 376 chemo). Data cutoff for interim OS/final PFS analysis was July 2, 2020. The secondary end point was ORR (RECIST v1.1 by investigator) in all pts. Primary end points were OS in pts with ESCC PD-L1 combined positive score (CPS) ≥10 tumors, and OS and PFS (RECIST v1.1 by investigator) in ESCC, PD-L1 CPS ≥10, and all pts. Treatment continued until progression, unacceptable toxicity, or withdrawal, or 2 yr. Randomization was stratified by Asia vs Rest of World, adenocarcinoma vs ESCC, and ECOG PS 0 vs 1. MethodsĮligible pts were randomized 1:1 to pembro 200 mg or placebo Q3W for up to 2 yr + chemo (cisplatin 80 mg/m2 Q3W + 5-FU 800 mg/m2 on d1-5 Q3W). KEYNOTE-590 (NCT03189719) is a randomized, international, double-blind study of 1L pembrolizumab (pembro) + chemotherapy (chemo) vs chemo alone in patients (pts) with locally advanced/unresectable or metastatic adenocarcinoma or esophageal squamous cell carcinoma (ESCC) or Siewert type 1 esophagogastric junction adenocarcinoma (EGJ). 18 Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, 100142 - Beijing/CN.17 Medical Oncology, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., 07033 - Kenilworth/US.16 Hematology-oncology, Hematology Oncology Practice Eppendorf, and University Cancer Center Hamburg, 20249 - Hamburg/DE.15 Medical Oncology, Vall d’Hebron Institute of Oncology, 08035 - Barcelona/ES. ![]() ![]() 14 Medicine, Prince of Songkla University Hospital, 90110 - Songkhla/TH. ![]()
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